The Rione Terra has been the only place that has evolved from the Greek-Roman colonization to modern times. In Roman times, Pozzuoli (Puteoli at that time) reached its peak. It was the major port in Rome until the rise of Ostia. After the rise of Ostia and the fall of the Roman Empire, Pozzuoli declined and its vastness reduced to just the Rione Terra.

Since then, around 400 A.C., cultures have followed and built homes and shops on the Roman remains, making the town fascinating, mysterious and popular. An example of this is the Cathedral of Pozzuoli dedicated to St. Procolo, a religious centre greeting thousands of faithful from all over the world. The cathedral was built during the Spanish period and has kept a secret for many years.