Italian Americans are most densely concentrated in the northeastern region of the US. Connecticut has the highest percentage of Italian Americans with 16.1%, followed by Rhode Island with 15.5% and New Jersey with 14.6%. These states also have some of the highest total numbers of Italian Americans, at 584,128, 169,515, and 1,353,075 respectively. New York has the largest total population of Italian Americans at 2,330,336, but a lower percentage of 11.9%.

Italian Americans are also present in significant numbers in other regions of the country. California has the second-largest total number of Italian Americans at 1,388,956, but a lower percentage of 3.6%. Texas has a similarly low percentage of Italian Americans at 1.7%, but due to its large population, it still has over half a million Italian Americans. The lowest percentages of Italian Americans are found in North Dakota and South Dakota, both with less than 1.2%.