Researchers say they have found the earliest representation of transplant surgery in a painting that depicts a scene from somewhere around the 5 th century AD, at least 1,400 years before modern medical practitioners first theorized transplantation.

The 14 th century painting, which is in the North Carolina Art Museum in Raleigh, North Carolina, United States, shows the story of a purported miracle by the physician Saints Cosmas and Damian, who, according to legend, took a healthy leg from a deceased man and replaced the gangrenous leg of a living man.

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Source: http://www.ancient-origins.net/