Visitors to the Cleveland Museum of Art's Italian Trecento gallery will notice that it is dominated by a painting from Tuscany. An altarpiece painted by the Sienese artist, Ugolino di Nerio da Siena (about 1280-1349), forms a major sightline object in that gallery.

Dating to about 1317, the altarpiece has survived nearly 700 years relatively intact. It is admired by thousands of visitors each year. The particular choice of saints on this altarpiece suggests that it was made for a Franciscan church, though its original location and placement remains unknown.

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Source: http://www.lagazzettaitaliana.com