Hollywood has a host of famous acting duos — Leonardo DiCaprio and Kate Winslet, Drew Barrymore and Adam Sandler, Matt Damon and Ben Affleck, just to name a few. But these killer pairings aren't a new phenomenon.

Viewers have been falling in love with actors' on-screen chemistry for decades, leading to subsequent partnerships that seemed to only get better with time and familiarity. Among those is Robert De Niro and Joe Pesci, who have shared the big screen a whopping six times throughout the years, IMDb indicates.