When you tell Carla Sozzani that fashion people, those elusive creatures, rarely find their way to Manhattan’s South Street Seaport neighborhood, where the latest edition of her landmark shop, 10 Corso Como, opens on September 6, she is undaunted. “They will come! It will be a destination! I love that this area is so historic and so near the water—I don’t think there is another place in New York I like better.”

The new store—a near-28,000-square-foot expanse one block from the East River—is housed in one of the former Fulton Fish Market buildings and was designed by Sozzani’s partner, artist Kris Ruhs. Mackerel have made way for Maison Margiela; instead of perch piled high on sopping counters, you’ll find Prada heels. A sleek restaurant is center stage—and, of course, Sozzani confirms with a laugh, fish will be prominent on the menu.